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Here’s an excerpt from this blog by Tara Brach:

In the Buddhist tradition, the Pali word dukkha is used to describe the emotional pain that runs through our lives. While it’s often translated as “suffering,” dukkha encompasses all our experiences of stress, dissatisfaction, anxiety, sorrow, frustration, and basic unease in living. But if we listen deeply, we will detect beneath the surface of all that troubles us an underlying sense that we are alone and unsafe, that something is wrong with our life.

The Buddha taught that this experience of insecurity, isolation, and basic “wrongness” is unavoidable. We humans, he said, are conditioned to feel separate and at odds with our changing and out-of-control life. And from this core feeling unfolds the whole array of our disruptive emotions—fear, anger, shame, grief, jealousy—all of our limiting stories, and the reactive behaviors that add to our pain.

Yet, the Buddha also offered a radical promise, one that Buddhism shares with many wisdom traditions: We can find true refuge within our own hearts and minds—right here, right now, in the midst of our moment-to-moment lives. We find true refuge whenever we recognize the silent, awake space of awareness behind all our busy doing and striving. We find refuge whenever our hearts open with tenderness and love. Presence, the immediacy and aliveness and warmth of our intrinsic awareness, creates a boundless sanctuary where there’s room for everything in our life.